For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings.
We hope this provides you with a helpful resource to make informed decisions towards your health and well-being. For a supplement, little scientific support. DMSO , or dimethyl sulfoxide, has a long history as a topical anti-inflammatory agent. Certain precautions must be taken when applying DMSO, and it should only be used under the guidance of a qualified healthcare professional. The use of dimethyl sulfoxide DMSO for therapeutic applications is controversial in part because some claims made by advocates appear to extend beyond current scientific evidence, and in part because topical use greatly increases the absorption of any substance that happens to be on the skin, including molecules that are toxic to the body.
Nonetheless, there is some preliminary evidence that when applied to the skin, it has anti-inflammatory properties and alleviates pain, such as that associated with RA.
DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves. It comes in different strengths and degrees of purity, and certain precautions must be taken when applying DMSO. For these reasons, DMSO should be used only under the supervision of a doctor. DMSO applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the abnormal connective tissue associated with disorders such as Dupuytren's contracture, keloids, Peyronie's disease, and scleroderma.
Research on the use of topical DMSO to treat Dupuytren's contracture remains preliminary and unproven. Oral supplementation with dimethyl sulfoxide DMSO reduced relapse rates for peptic ulcer significantly better than did placebo or the ulcer drug cimetidine Tagamet in one study.
Previous research showed that DMSO in combination with cimetidine was more effective than cimetidine alone. These trials used mg of DMSO taken four times per day.
The authors of these trials believe the antioxidant activity of DMSO may have a protective effect. Oral supplementation with DMSO should not be attempted without the supervision of a doctor. The use of DMSO , a colorless, oily liquid primarily used as an industrial solvent, for therapeutic applications is controversial.
However, some evidence indicates that dilutions, when applied directly to the skin, have anti-inflammatory properties and inhibit the transmission of pain messages by nerves, and in this way might ease the pain of minor injuries such as sprains and strains.
However no controlled research exists to confirm these effects in sprains and strains. DMSO comes in different strengths and different degrees of purity. In addition, certain precautions must be taken when applying DMSO. For those reasons, DMSO should be used only with the supervision of a doctor. DMSO is not indicated for healthy people. Those who do use this substance should consult a doctor familiar with its use. Because it pulls water from tissues, DMSO has a diuretic effect, meaning it makes a horse urinate more.
This can help flush toxins from the body more quickly. With this action in mind, DMSO is often given intravenously in the treatment of cantharidin poisoning blister beetle toxicity , to lessen the effect of the toxin on the kidneys and intestinal tract. After episodes of tying up, DMSO may help horses eliminate waste products of muscle breakdown through their urine more quickly. The diuretic action of DMSO, however, can make it unsafe for horses who are dehydrated or in shock.
It can further dehydrate these animals or dangerously lower their blood pressure. For instance, treating rainrot or other skin infections can be difficult because the responsible organisms are buried deep under the skin or crusty, painful scabs. However, a mixture combining antibacterial medication with DMSO can pass through the skin and reach the affected area. For the same reason, DMSO is often added to antifungal medications for treatment of eye conditions and sometimes to steroids for targeted, topical anti-inflammatory treatment.
Likewise, avoid mixing DMSO with substances that could be toxic if ingested, such as organophosphates or mercury salt. Research shows that DMSO slows or blocks conduction of impulses along nerve cells, which in effect reduces pain from musculoskeletal injuries, postoperative incisions and other sources.
Relief is only temporary—lasting up to a few hours—because as the DMSO dissipates, normal nerve function returns. It can be combined with other pain-relieving drugs, however, to extend the analgesic action. Some applications of DMSO combine all of these: For instance, it is often used in surgical colic cases to reduce the risk of tissue adhesions due to inflammation and poor circulation; some surgeons think that it may also provide some pain relief in the hours following surgery.
The Jockey Club allows 10 micrograms per milliliter of plasma. If you compete with your horse, check any governing association rules regarding DMSO use. Also keep in mind that because DMSO can move other materials through the skin, combining it with other medications could result in a violation of thresholds for both.
A search of a research database will turn up a good sampling of peer-reviewed papers on DMSO use in horses, but the compound has gotten far less scientific scrutiny than have medications developed specifically for therapeutic applications. Scant information is available regarding dosing. Often veterinarians rely on their own experiences and those of their colleagues in deciding when and how to use DMSO. Whether applied topically, orally, intravenously or by injection, DMSO requires careful handling.
If you do, keep these basic facts in mind to make sure your horse benefits fully from this unusual preparation. Don't miss out! With the free weekly EQUUS newsletter, you'll get the latest horse health information delivered right to your in basket! Behavioral Problems. Medications and Drugs. Horse Care. Farm and Ranch. Hoof Care. Specifically, DMSO may help treat chemotherapy extravasations.
This condition occurs when the drugs used to treat cancer leak and become trapped in surrounding tissues. It can cause symptoms that include:. However, more research is needed to assess the potential benefits and risks of using DMSO to treat these conditions. This is a chronic condition that causes inflammation in your bladder. To treat it, your doctor may flush DMSO into your bladder using a catheter over several of weeks.
While DMSO has been approved for a variety of uses in dogs and horses, interstitial cystitis remains its only FDA-approved use in humans. The use of DMSO in animals has been linked to changes to their eye lenses. This has raised concerns about the potential of DMSO to damage human eyes.
More research is needed to assess these risks. Other reported side effects from DMSO tend to be minor. The most commonly reported side effect is a strong garlic flavor in your mouth for several hours after you have been treated with it. Your skin may also give off a garlic-like odor for up to 72 hours after being treated. Doctors agree that you should be cautious when it comes to applying DMSO topically. It may cause dry, scaly, and itchy skin. It may also interact with other medications.
Unhealthy substances may also be absorbed through your skin along with the DMSO. And it may also cause urine discoloration and agitation.
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